In this article, Arthur D. Little's new report which states that by 2020, pharmaceutical business models will be turned on their head because of digital health is discussed. Innovation outside the healthcare space is causing disruption to the pharmaceutical company, its strategy and the way in which it operates. These new systems and products range widely but all make use of advances in digital technologies and the ability to analyse and present large amounts of data in new ways. The article discusses six success factors that are key for pharma companies wanting to respond to the disruptive pressure caused by new digital offerings.